The Korea Disease Control and Prevention Agency (KDCA) has urged the public to adhere to COVID-19 prevention guidelines—such as regular handwashing, periodic indoor ventilation, and practicing proper cough etiquette—to protect high-risk groups like the elderly and immunocompromised individuals. This is because the number of weekly COVID-19 hospitalizations at hospital-level medical institutions continues to rise. Therefore, we provide the following COVID-19 infection prevention guidelines.