자기소개  및  관심연구분야

: I received my Ph.D. at the University of Tennessee, Knoxville where my research investigated the unique metabolism of butyrate, a microbiota-derived metabolite by colorectal cancer cells. I commenced post-doctoral training at the Sidney Kimmel Cancer Center at Thomas Jefferson University in Philadelphia. During my postdoc period, my research interests included: 1) understanding of specific metabolic characteristics of uveal melanoma (UM), a rare eye cancer, and 2) investigating the metabolic functions of BRCA1-associated protein 1 (BAP1) in UM to broaden therapeutic options and rationale for novel treatment options for advanced UM. I also worked on targeting mechanisms of intrinsic resistance to targeted therapies and understanding the correlation between metabolism and dormancy in UM. 

Based on my interests in cancer metabolism, now I aim to investigate the anti-cancer and preventive effects of bioactive compounds, especially coming from Korean traditional foods in gastrointestinal (GI) tract cancers (i.e., pancreatic, gastric, and colorectal cancer). Additionally, I also have interests in nutritional translational studies, including diabetes, obesity, and osteoporosis along with pre-clinical studies.

키워드: 생리활성물질, 암, 대사, 항암효과, 소화계암(췌장, 위, 대장  등), 전임상연구, 임상연구

2005 전북대학교 식품영양학과 학사 (부전공: 경영학)
2009 서울대학교 식품영양학 석사
2013 The University of Tennessee, Knoxville, 영양학박사

2005 B.S. in Science in Food Science and Human Nutrition, Jeonbuk National University, Korea
2009 M.S. in Science in Food and Nutrition, Seoul National University, Korea
2013 Ph.D. in Cellular and Molecular Nutrition, University of Tennessee, Knoxville, TN, USA

2011-2013 한국식품연구원 연구 인턴쉽 및 연구보조원
2017-2021 Thomas Jefferson University (NCI-designated-Sidney Kimmel Cancer Center) 박사후 연구원
2021.09- 전북대학교 식품영양학과 조교수

2011-2013 Research Assistant, Korea Food Research Institute, Wanju-gun, Korea
2017-2021 Post-doctoral Fellow, Thomas Jefferson University, Philadelphia, PA, USA
2021.9- Assistant Professor, Department of Food Science and Human Nutrition, Jeonbuk National University, Korea

기초영양학(Basal Nutrition), 고급영양학(Advanced Nutrition), 생애주기영양학(Nutrition Through
the Life Cycle), 영양학특론(Advanced Nutrition), 고급영양이론(Advanced Nutrition)

1)논문 (Publications)
Han A, Choi YJ. Comparison of Metabolic Syndrome (MetS) Risk and Nutritional Status According to Menopause Age and the Impact of Socioeconomic Status on MetS Prevalence in Postmenopausal Women: A Cross-Sectional Study Based on the 8th Korea National Health and Nutrition Examination Survey (KNHANES). Nutrients. 2024;16(7):967. Published 2024 Mar 27. doi:10.3390/nu16070967
Han A, Mukha D, Chua V, et al. Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth. Cancers (Basel). 2023;15(13):3451. Published 2023 Jun 30. doi:10.3390/cancers15133451
Lee H, Song J, Chung S, Cha YS, Han A. Gochujang elicits anti-obesity effects by increasing capsaicin-independent brown adipogenesis and thermogenesis in high-fat diet induced obese mice. Journal of Functional Foods. 2023 Dec 1;111:105886.
Woo H, Han A, Park JE, Cha YS. Korean fermented soybean paste (Doenjang) has anti-obesity and anti-hypertensive effects via the renin-angiotensin system (RAS) in high-fat diet-induced obese rats. PLoS One. 2023;18(10):e0291762. Published 2023 Oct 20. doi:10.1371/journal.pone.0291762
Kim NY, Kim KA, Yang HJ, Jeong SJ, Han A, Cha YS. Comparison of the laxative effects of Korean Gochujang containing different microbiota on loperamide-induced constipation in ICR mice. Food Funct. 2023;14(16):7615-7630. Published 2023 Aug 14. doi:10.1039/d2fo04111a
Lee EJ, Edward OC, Seo EB, EG Mun, SJ Jeong, GW Ha, Han A, et al. Gochujang Ameliorates Hepatic Inflammation by Improving Dysbiosis of Gut Microbiota in High-Fat Diet-Induced Obese Mice. Microorganisms. 2023;11(4):911. Published 2023 Mar 31. doi:10.3390/microorganisms11040911
Edward OC, Lee EJ, Han A, et al. Gochujang Consumption Prevents Metabolic Syndrome in a High-Fat Diet Induced Obese Mouse Model. J Med Food. 2023;26(4):244-254. doi:10.1089/jmf.2022.K.0126
Han A, Chua V, Baqai U, et al. Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma. Oncogene. 2022;41(8):1129-1139. doi:10.1038/s41388-021-02154-0
Han A, Park Y, Lee YK, Park SY, Park CY. Position Statement: Vitamin D Intake to Prevent Osteoporosis and Fracture in Adults. J Bone Metab. 2022;29(4):205-215. doi:10.11005/jbm.2022.29.4.205
Lee EJ, Song J, Park CH, EG Mun, Jinxi Wang, Han A, et al. Soy Sauce Lowers Body Weight and Fat Mass in High-Fat Diet-Induced Obese Rats. J Med Food. 2023;26(11):858-867. doi:10.1089/jmf.2022.K.0125
Edward OC, Thomas SS, Cha KO, Jung HA, Han A, Cha YS. Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice. Nutr Res Pract. 2022;16(5): 549-564.doi:10.4162/nrp.2022.16.5.549
Baqai U, Purwin TJ, Bechtel N, Chua V, Han A, et al. Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma. Mol Cancer Res. 2022;20(8):1260-1271. doi:10.1158/1541-7786.MCR-21-0657
Han A, Schug ZT, Aplin AE. Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma. Trends Cancer. 2021;7(8):671-681. doi:10.1016/j.trecan.2021.05.005
Han A, Purwin TJ, Aplin AE. Roles of the BAP1 Tumor Suppressor in Cell Metabolism. Cancer Res. 2021;81(11):2807-2814. doi:10.1158/0008-5472.CAN-20-3430
Han A, Purwin TJ, Bechtel N, et al. BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors [published correction appears in Oncogene. 2021 Mar;40(9):1753]. Oncogene. 2021;40(3):618-632. doi:10.1038/s41388-020-01554-y
Kim D, Han A, Park Y. Association of Dietary Total Antioxidant Capacity with Bone Mass and Osteoporosis Risk in Korean Women: Analysis of the Korea National Health and Nutrition Examination Survey 2008-2011. Nutrients. 2021;13(4):1149. Published 2021 Mar 31. doi:10.3390/nu13041149
Chua V, Mattei J, Han A, et al. The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019). Clin Cancer Res. 2021;27(1):28-33. doi:10.1158/1078-0432.CCR-20-2536
Teh JLF, Purwin TJ, Han A, et al. Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma. Mol Cancer Ther. 2020;19(8):1719-1726. doi:10.1158/1535-7163.MCT-19-1016
Han A, Bennett N, Ahmed B, Whelan J, Donohoe DR. Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases. Oncotarget. 2018;9(43):27280-27292. Published 2018 Jun 5. doi:10.18632/oncotarget.25546
MacDonald AF, Bettaieb A, Donohoe DR, Alani Ds, Han A, et al. Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. BMC Complement Altern Med. 2018;18(1):188. Published 2018 Jun 18. doi:10.1186/s12906-018-2255-0
Han A, Won SB, Kwon YH. Different Effects of Maternal Low-Isoflavone Soy Protein and Genistein Consumption on Hepatic Lipid Metabolism of 21-Day-Old Male Rat Offspring. Nutrients. 2017;9(9):1039. Published 2017 Sep 20. doi:10.3390/nu9091039
Won SB, Han A, Kwon YH. Maternal consumption of low-isoflavone soy protein isolate alters hepatic gene expression and liver development in rat offspring. J Nutr Biochem. 2017;42:51-61.doi:10.1016/j.jnutbio.2016.12.013
Johnstone M, Bennett N, Standifer C, Smith A, Han A et al. Characterization of the Pro-Inflammatory Cytokine IL-1β on Butyrate Oxidation in Colorectal Cancer Cells. J Cell Biochem. 2017;118(6):1614-1621. doi:10.1002/jcb.25824
Han A, Bennett N, MacDonald A, Johnstone M, Whelan J, Donohoe DR. Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells. J Cell Physiol. 2016;231(8):1804-1813. doi:10.1002/jcp.25287
Burke SJ, Stadler K, Lu D, Cleason EL, Han A, et al. IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB. Am J Physiol Endocrinol Metab. 2015;309(8):E715-E726. doi:10.1152/ajpendo.00153.2015
Park SJ, Park JH, Han A, et al. Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells via activation of AMP-activated protein kinase. Cell Biochem Funct. 2015;33(4):220-225. doi:10.1002/cbf.3107
Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, Curry KP, Renner SW, Greenwalt A, Ryan EP, Godfrey V, Heise MT, Threadgill DS, Han A, Swenberg JA, Threadgill DW, Bultman SJ. A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner. Cancer Discov. 2014;4(12):1387-1397. doi:10.1158/2159-8290.CD-14-0501
Jung GY, Won SB, Kim J, Jeon S, Han A, Kwon YH. Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice. Toxicol Res. 2013;29(1):7-14. doi:10.5487/TR.2013.29.1.007

- 10-히드록시캄토테신을 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 조성물 (등록번호:1013713540000). 2014
- 데옥시시코닌을 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 조성물 (등록번호: 1013683830000), 2014
- 바바치닌 Ａ를 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 조성물 (등록번호:1013490890000), 2014
Ｓ-아릴 시스테인을 유효성분으로 함유하는 비만으로 유도된 염증 치료용 조성물 (등록번호:1014956070000), 2015

- H.J. Hur, H.J. Yang, K.W. Lee, S.J. Park, Han A., Composition for prevention and treatment of obesity or metabolic diseases comprising 10-hydroxycamptothecin. Korea Patent (1013713540000), 2014
- H.J. Hur, H.J. Yang, K.W. Lee, S.J. Park, Han A., Composition for prevention and treatment of obesity or metabolic diseases comprising Deoxyshikonin. Korea Patent (1013683830000),
2014.
- H.J. Hur, H.J. Yang, K.W. Lee, S.J. Park, Han A., Composition for prevention and treatment of obesity or metabolic diseases comprising Bavachinin A. Korea Patent (1013490890000),
2014.
- H.J. Hur, H.J. Yang, K.W. Lee, S.J. Park, Han A., Composition of comprising S-Allyl-LCysteine for treating obesity-induced inflammation. Korea Patent (1014956070000), 2015.