프로필

• 최종 학위 논문Crystal structure of ligand-free G-protein-coupled receptor opsin
• 2002.08.01 ~ 2010.02.17베를린 훔볼트대학교 생물학부 생물리학과(이학박사)
• 1999.03.02 ~ 2001.02.22전북대학교 자연과학대학 화학과(이학석사)
• 1992.03.02 ~ 1999.02.22전북대학교 자연과학대학 화학과(이학사)

• 2009.01.01 ~ 2010.12.31샤리테 의과대학, 물리 및 생물리학 연구소, 박사후연구원
• 2005.01.01 ~ 2008.12.31샤리테 의과대학, 물리 및 생물리학 연구소, 연구원

• 2008.10.2561주년 전북대학교 개교기념, 13회 전북대학교 동문 대상
• 2002.08 ~ 2004.12연구 장학금, 독일 베를린 샤리테 의과대학, 의학 물리 및 생물리학 연구소
• 2001.03 ~ 2002.08연구 장학금, 독일 베를린 샤리테 의과대학, 의학 물리 및 생물리학 연구소

• 2013.01 ~ 현재대한 면역학회 회원
• 2013.01 ~ 현재한국 구조 생물학회 회원
• 2012.01 ~ 현재한국분자세포생물학회 회원
• 2008.01 ~ 2010.12독일 생물리학 회원 (DGfB)

Protein crystallography is one of methods to determine protein structures at the atomic level and enhances our understanding of protein function in various biological system. The method generally enables us to provide many information of proteins with visualized effects that can be elucidated their structural-functional relationship in biological system.

For examples

• Interactions of proteins with other molecules, i.e. Protein - Protein, Protein - Ligand interactions, etc.
• Conformational changes induced by allosteric regulation, i.e. Allosteric Activators and Allosteric Inhibitors
• Enzyme Catalysis

My current major research interests are on the crystallization and structural analysis of several photoreceptors that are able to uptake some signals involving in various signal transduction cascades. Based on these information, we can provide various templates to design novel drugs that target a particular protein, or rationally engineer an enzyme for a specific industrial process.

For examples in visual signal transduction cascade

• Activation pathway in visual signal transduction cascade

• Inactive and active conformations of rhodopsin (or Opsin*) and signal transfer to the G protein

• Conserved E(D)RY and NPxxY(x)5,6F regions (Switch Regions).

Refs.

• 1. Park, J. H., Scheerer, P., Hofmann, K. P., Choe, H.-W. & Ernst, O. P. Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 454, 183-187 (2008).
• 2. Scheerer, P., Park, J. H., Hildebrand, P. W., Kim, Y. J., Krauss, N., Choe, H.-W., Hofmann, K. P. & Ernst, O. P. Crystal structure of opsin in its G-protein-interacting conformation. Nature 455, 497-502 (2008).
• 3. Choe, H. W., Kim, Y. J., Park, J. H., Morizumi, T., Pai, E. F., Krauss, N., Hofmann, K. P., Scheerer, P., Ernst, O. P.Crystal structure of metarhodopsin II. Nature 471, 651-655 (2011)